The Safety of the Isuzu MU-X are as follow:
| Variants | 2018 Isuzu MU-X 2.5L 4x2 AT | 2018 Isuzu MU-X 2.5L 4x4 AT |
| Euro NCAP Rating | None | None |
| ASEAN NCAP Rating | None | None |
| Airbags | 2 | 2 |
| Driver/Front Passenger Seat Airbags | Y/Y | Y/Y |
| Front/Rear Side Airbags | - | - |
| Front/Rear Curtain Airbags | - | - |
| Knee Airbags | ||
| Rear Airbags | ||
| Airbag Disable Function | ||
| Seatbelt Reminder | Front Seats Only | Front Seats Only |
| Autonomous Emergency Braking | N | N |
| Lane-keeping Alert | N | N |
| Blind Spot Info System | N | N |
| Collision Warning | N | N |
| ABS/EBD | Y | Y |
| Electronic Stability Control(ESC) | Y | Y |
| Child Safety Lock | Manual for Rear Doors | Manual for Rear Doors |
| ISOFIX | Y | Y |
| Security Alarm | Y | Y |
| Immobilizer | Y | Y |
