The Safety of the Mercedes-Benz AMG GLC Coupe are as follow:
| Variants | 2018 Mercedes-Benz AMG GLC Coupe AMG GLC 43 4MATIC Coupe | 2018 Mercedes-Benz AMG GLC Coupe AMG GLC 63 S 4MATIC+ Coupe |
| Euro NCAP Rating | 10 | 0 |
| ASEAN NCAP Rating | 0 | 0 |
| Airbags | 7 | 7 |
| Driver/Front Passenger Seat Airbags | Y/Y | Y/Y |
| Front/Rear Side Airbags | - | - |
| Front/Rear Curtain Airbags | Y/Y | Y/Y |
| Knee Airbags | Driver Knee | Driver Knee |
| Rear Airbags | ||
| Airbag Disable Function | Y | Y |
| Seatbelt Reminder | For All Seats | All Seats |
| Autonomous Emergency Braking | Y | Y |
| Lane-keeping Alert | N | Y |
| Blind Spot Info System | - | Y |
| Collision Warning | Y | Y |
| ABS/EBD | Y | Y |
| Electronic Stability Control(ESC) | Y | Y |
| Child Safety Lock | Manual for rear doors | Manual for rear doors |
| ISOFIX | Y | Y |
| Security Alarm | Y | |
| Immobilizer | Y | Y |
