The Interior of the Nissan Serena S-Hybrid are as follow:
| Variants | 2018 Nissan Serena S-Hybrid Highway Star 2.0 | 2018 Nissan Serena S-Hybrid Premium Highway Star 2.0 |
| Sunroof | - | - |
| Sunshade | Manual rear door window shades | Manual rear door window shades |
| Seat Features(Front-Driver) | Manual Adjustable | Manual Adjustable |
| Seat Features(Passenger) | ||
| Seat Features(Rear) | Manual reclining and sliding middle row captain seats, Last Row 50:50 Split-folding and Flip-up | Manual reclining and sliding middle row captain seats, Last Row 50:50 Split-folding and Flip-up |
| Cupholders | 2 Front, 4 Middle Row, 4 Last Row | 2 Front, 4 Middle Row, 4 Last Row |
| Front Air-con | Single-zone Automatic Climate Control System | Single-zone Automatic Climate Control System |
| Rear Air-con | Y | Y |
| Paddle Shift | - | - |
| Multi-function Steering Wheel | ||
| Steering Tilt | Y | Y |
| Steering Telescopic | Y | Y |
| Steering Adjustment Electric | ||
| Engine Start | Keyless Push Button | Keyless Push Button |
| Head-up Display | - | - |
