The Safety of the Lexus NX are as follow:
| Variants | 2019 Lexus NX 300 Urban | 2019 Lexus NX 300 Premium | 2019 Lexus NX 300 F Sport |
| Euro NCAP Rating | 10 | 10 | 10 |
| ASEAN NCAP Rating | |||
| Airbags | 8 | 8 | 8 |
| Driver/Front Passenger Seat Airbags | Y/Y | Y/Y | Y/Y |
| Front/Rear Side Airbags | Y/Y | Y/Y | Y/Y |
| Front/Rear Curtain Airbags | Y/Y | Y/Y | Y/Y |
| Knee Airbags | Driver Knee | Driver Knee | Driver Knee |
| Rear Airbags | Y | Y | Y |
| Airbag Disable Function | N | N | N |
| Seatbelt Reminder | For All Seats | For All Seats | For All Seats |
| Autonomous Emergency Braking | Y | Y | Y |
| Lane-keeping Alert | Y | Y | Y |
| Blind Spot Info System | N | Y | N |
| Collision Warning | Y | Y | Y |
| ABS/EBD | Y | Y | Y |
| Electronic Stability Control(ESC) | |||
| Child Safety Lock | Manual for rear doors | Manual for rear doors | Manual for rear doors |
| ISOFIX | Y | Y | Y |
| Security Alarm | Y | Y | Y |
| Immobilizer | Y | Y | Y |
