The Safety of the Mercedes-Benz GLC are as follow:
| Variants | 2020 Mercedes-Benz GLC 200 | 2020 Mercedes-Benz GLC 300 4Matic | 2018 Mercedes-Benz GLC GLC 200 | 2018 Mercedes-Benz GLC GLC 250 4Matic AMG Line |
| Euro NCAP Rating | 10 | 10 | ||
| ASEAN NCAP Rating | 0 | 0 | ||
| Airbags | 7 | 7 | ||
| Driver/Front Passenger Seat Airbags | Y/Y | Y/Y | ||
| Front/Rear Side Airbags | - | - | ||
| Front/Rear Curtain Airbags | Y/Y | Y/Y | ||
| Knee Airbags | Driver Knee | Driver Knee | ||
| Rear Airbags | ||||
| Airbag Disable Function | Y | Y | ||
| Seatbelt Reminder | For All Seats | For All Seats | ||
| Autonomous Emergency Braking | Y | |||
| Lane-keeping Alert | Y | N | ||
| Blind Spot Info System | Y | Y | - | |
| Collision Warning | Y | |||
| ABS/EBD | Y | Y | Y | |
| Electronic Stability Control(ESC) | Y | |||
| Child Safety Lock | Manual for rear doors | Manual for rear doors | ||
| ISOFIX | Y | Y | Y | |
| Security Alarm | Y | |||
| Immobilizer | Y | Y | Y |
