The Safety of the Mercedes-Benz S-Class Cabriolet are as follow:
| Variants | 2018 Mercedes-Benz S-Class Cabriolet S 560 AMG Line |
| Euro NCAP Rating | 0 |
| ASEAN NCAP Rating | 0 |
| Airbags | 10 |
| Driver/Front Passenger Seat Airbags | Y/Y |
| Front/Rear Side Airbags | Y/Y |
| Front/Rear Curtain Airbags | Y/Y |
| Knee Airbags | |
| Rear Airbags | |
| Airbag Disable Function | Y |
| Seatbelt Reminder | All Seats |
| Autonomous Emergency Braking | |
| Lane-keeping Alert | |
| Blind Spot Info System | |
| Collision Warning | |
| ABS/EBD | |
| Electronic Stability Control(ESC) | |
| Child Safety Lock | - |
| ISOFIX | |
| Security Alarm | |
| Immobilizer |
