The Interior of the Mercedes-Benz S-Class Cabriolet are as follow:
| Variants | 2018 Mercedes-Benz S-Class Cabriolet S 560 AMG Line |
| Sunroof | - |
| Sunshade | - |
| Seat Features(Front-Driver) | 12-Way Power-Adjustable Seats with Memory Function |
| Seat Features(Passenger) | |
| Seat Features(Rear) | Centre Armrest |
| Cupholders | |
| Front Air-con | Dual-zone Automatic Climate Control System |
| Rear Air-con | |
| Paddle Shift | |
| Multi-function Steering Wheel | Y |
| Steering Tilt | Y |
| Steering Telescopic | Y |
| Steering Adjustment Electric | Y |
| Engine Start | Keyless Push Button |
| Head-up Display |
