The Safety of the Mercedes-Benz AMG C-Class Coupe are as follow:
| Variants | 2018 Mercedes-Benz AMG C-Class Coupe C 63 S | 2018 Mercedes-Benz AMG C-Class Coupe AMG C 43 4MATIC |
| Euro NCAP Rating | 10 | 10 |
| ASEAN NCAP Rating | None | None |
| Airbags | 7 | 7 |
| Driver/Front Passenger Seat Airbags | Y/Y | Y/Y |
| Front/Rear Side Airbags | - | - |
| Front/Rear Curtain Airbags | Y/Y | Y/Y |
| Knee Airbags | Driver Knee | Driver Knee |
| Rear Airbags | ||
| Airbag Disable Function | Y | Y |
| Seatbelt Reminder | All Seats | For All Seats |
| Autonomous Emergency Braking | Y | Y |
| Lane-keeping Alert | - | N |
| Blind Spot Info System | - | - |
| Collision Warning | Y | Y |
| ABS/EBD | Y | Y |
| Electronic Stability Control(ESC) | Y | Y |
| Child Safety Lock | Manual for rear doors | - |
| ISOFIX | Y | Y |
| Security Alarm | Y | Y |
| Immobilizer | Y | Y |
