The Interior of the Mercedes-Benz AMG E-Class are as follow:
| Variants | 2018 Mercedes-Benz AMG E-Class AMG E 63 S 4MATIC+ |
| Sunroof | Panoramic |
| Sunshade | Powered rear sun shade, manual rear door window sun shades |
| Seat Features(Front-Driver) | Power Adjustable Seats with Memory Function |
| Seat Features(Passenger) | |
| Seat Features(Rear) | 40:20:40 Split-folding |
| Cupholders | 2 Front, 2 Rear |
| Front Air-con | Dual-zone Automatic Climate Control System |
| Rear Air-con | Y |
| Paddle Shift | Y |
| Multi-function Steering Wheel | Y |
| Steering Tilt | Y |
| Steering Telescopic | Y |
| Steering Adjustment Electric | Y |
| Engine Start | Keyless Push Button |
| Head-up Display | Y |
