The Safety of the Mercedes-Benz GLC Coupe are as follow:
| Variants | 2020 Mercedes-Benz GLC 300 4MATIC Coupé |
| Euro NCAP Rating | |
| ASEAN NCAP Rating | |
| Airbags | |
| Driver/Front Passenger Seat Airbags | |
| Front/Rear Side Airbags | |
| Front/Rear Curtain Airbags | |
| Knee Airbags | |
| Rear Airbags | |
| Airbag Disable Function | |
| Seatbelt Reminder | |
| Autonomous Emergency Braking | |
| Lane-keeping Alert | Y |
| Blind Spot Info System | Y |
| Collision Warning | Y |
| ABS/EBD | Y |
| Electronic Stability Control(ESC) | |
| Child Safety Lock | |
| ISOFIX | Y |
| Security Alarm | Y |
| Immobilizer | Y |
